science

APOE4 Gene Linked to Neuron Shrinkage Before Alzheimer’s Symptoms Appear

23 Ağustos 2026Science Daily

Researchers have identified how the Alzheimer’s risk gene APOE4 may affect brain function years before memory issues arise. In studies with mice, the presence of APOE4 led to an increase in the protein Nell2, resulting in the shrinkage of neurons and heightened activity in memory circuits.
This early hyperactivity was linked to poorer memory outcomes later in life. Importantly, reducing Nell2 in adult mice was able to reverse these changes, suggesting potential intervention strategies for Alzheimer’s.
Alzheimer's disease is a complex neurodegenerative condition often characterized by gradual memory loss and cognitive decline. The APOE4 gene variant is known to increase the risk of developing Alzheimer's, but the mechanisms behind its effects have remained unclear.
The findings present a significant breakthrough in understanding the early biological processes associated with Alzheimer's disease. By pinpointing the role of the Nell2 protein, researchers may have uncovered a target for therapeutic intervention that could mitigate the effects of the APOE4 gene.

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This article is based on research findings and does not constitute medical advice. Always consult a healthcare professional for medical concerns.